The Tigers defeated Iowa State 7-0 on Saturday in Ames, Iowa, losing just three sets in the six singles matches.
Missouri improved to 10-11 overall and 2-7 in the Big 12 Conference.
Former Rock Bridge player Kara Hickey, now an Iowa State junior, fell to Missouri junior Jessica Giuggioli 7-6 (6), 3-6. 0-6 at No. 2 singles.