MU researcher advancing potential HIV prevention drug

Friday, November 13, 2009 | 12:01 a.m. CST; updated 12:31 a.m. CST, Friday, November 13, 2009

COLUMBIA — An HIV treatment drug has the potential to be up to 60,000 times more powerful than any other used, in part because of the work of MU researcher Stefan Sarafianos. 

Sarafianos, assistant professor of microbiology and immunology at MU, worked with researchers in Japan, as well as researchers from the University of Pittsburgh and the National Institutes of Health, to develop a compound known as EFdA, an HIV inhibitor that blocks viral replication.

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Centers for Disease Control and Prevention, 56,300 people were newly infected with HIV in 2006. In the U.S. alone, more than 1 million people live with HIV, and one in five of them do not know they are infected, according to the CDC.

More CDC statistics show that out of a pool of 54,230 HIV-infected Americans, 53 percent were men who have had sex with men, 31 percent heterosexuals, 12 percent transmitted the virus through injection drug use and 4 percent through injection drug use and/or a male having sex with another male.

"There are more than 20 drugs for the treatment of the virus, but there are none for the prevention. Not a single approved microbicide," Sarafianos said Thursday as he darted through the corridors of the School of Medicine.

Sarafianos was headed to Bryant Auditorium to receive the 2009 Dorsett L. Spurgeon, MD Distinguished Medical Research Award for his work. Roughly 100 students and medical professionals attended the ceremony.

He also gave a presentation on EFdA, demonstrating what potential the HIV inhibitor has in two primary categories. One is that the compound can block viral replication, lending itself as a potential therapeutic for individuals harboring multi-resistant HIV. Another is the potential to be a microbicide, or a product that could reduce HIV infections.

That, Sarafianos said, is what excites him most.

"Hopefully it will be picked up by a company and it will be developed as a microbicide and it will be cheap and accessible to many people not only in this country but also where it's needed most," he said. "I want to make a huge difference."

He said trying to patent the drug has been a challenge.

"Even though it's a fantastic compound, I think the big challenge now is companies are reluctant to go into new compounds," he said.

Some commercial preventative agents with which the HIV inhibitor could be marketed include vaginal gels, tablets and condoms.

EFdA prohibits HIV from replicating, Sarafianos said, by binding to reverse transcriptase — the enzyme that causes HIV to replicate — and blocking it.

"We have found that EFdA works with a very different mechanism," he said.

Sarafianos is optimistic about the patent process. "I think it's taking it's course," he said. "And it's getting there."

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Apostle Shada Mishe November 13, 2009 | 12:32 p.m.


is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH 'KILLS' the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to 'KILL' the virus that are 'hiding' in the lymph system by its 'natural radioactive' properties. This process allows the body to 'return to normal health' with a corresponding immunity to that or those strains of the virus.

What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the 'palm' plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a 'NEW' crystalline substance, a drug from the 'palm plant' similarly to ASPIRIN originating from the willow tree bark


Here is a video taped presentation that I gave at t he Martin Luther King library in Washington

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