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Kansas lab looked at synthetic marijuana's effect on brain

Wednesday, February 17, 2010 | 12:01 a.m. CST; updated 10:27 a.m. CST, Monday, February 22, 2010
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Marijuana, K2 and other synthetic marijuana variants contain active chemicals that cause psychoactive effects when consumed. They are part of a class of compounds known as cannabinoids. The cannabinoid in marijuana is the naturally occurring delta 9-tetrahydrocannabinol, or THC. The Johnson County Crime Lab in Kansas has identified two synthetic cannabinoids in K2: JWH-018 and JWH-073.

Cannabinoids act by binding to two types of nerve receptors known as CB1 and CB2. Both receptors are linked to proteins that regulate neurotransmission.

K2 compounds were produced in a laboratory at Clemson University. An earlier version of this story misidentified the substance that was produced there.

COLUMBIA — A legal substance that mimics the effects of marijuana is responsible for some hospitalizations across the country but has not proven to be a significant presence in mid-Missouri.

K2, a substance that state Sen. Kurt Schaefer, R-Columbia, wants to ban in Missouri, is a “non-issue” in Columbia, said Jessie Haden, Columbia Police public information officer. The Columbia police have not received reports of incidents involving the legal substance.

K2 is a combination of plant materials and two synthetic cannabinoids, according to Jeremiah Morris, a forensic scientist for the Johnson County Criminalistics Laboratory in Mission, Kan. The laboratory, an arm of the Johnson County Sheriff's Department,  ran an analysis on K2 in October 2009 after noticing an increase in use in Johnson County.

“They found K2 to contain lab-produced drugs that act on the same part of the brain as marijuana,” Morris said.

But the compounds in K2 are three to five times more potent than THC found in marijuana. Morris compared the effects of K2's compounds to a lock-and-key mechanism in which the lock is a receptor site of the brain and the key is the drug's compounds. The "keys" in K2 compounds are keys that fit the brain's "lock" better than those in marijuana.

The psychoactive drug can cause users to experience rapidly increased heart rates, loss of consciousness, paranoia and, occasionally, psychotic episodes. One hospitalized user claimed he could see his heart beating out of his chest. Individuals have different reactions to the drug, though users do not have to smoke excessively to experience potentially harmful symptoms, Morris said.

K2 compounds were produced in a laboratory at Clemson University in 1995 by a group of research students working under professor John Huffman, who was trying to explore how drug substances latch on to receptor sites in the brain. Morris said he believes that manufacturers of K2 created and sold the substance for drug use by studying Huffman’s research, published in 1998.

Morris said there has been little scientific research exploring the toxicity of K2 in the United States, but hospitalization cases have appeared in Florida, Maine and Arkansas, in addition to St. Louis, Springfield and Kansas City.

Scientific studies on K2 compounds were done using a drug called Spice that emerged in Germany in 2008. It was made up of plant materials and the same compounds as K2 and caused psychotic episodes that resulted in increased hospitalizations and accidents, Morris said.

These studies showed that those who ingest K2 compounds exhibit typical drug dependency signs, withdrawal symptoms and addictive behaviors associated with other drug use. Morris said that K2 and Spice are basically the same product with different names.

“We’re seeing exactly what Germany saw in 2008 and 2009,” Morris said.

Morris said that as people have begun to smoke K2 instead of marijuana, calls to poison control centers and emergency rooms have increased.

Though K2 has psychoactive properties, it is currently legal in Missouri and federally. Schaefer and other legislators hope to change this.

The House Public Safety Committee unanimously voted to pass a bill that, among other things, would make one of the ingredients in K2 illegal. 

The bill's next step is passage by the House Rules Committee. It could then go to a vote of the whole body.

Kim Dude, assistant director of the MU Wellness Resource Center said the center has no plans to incorporate K2 into their educational programs until more information is found about the drug.

“The noise is from the media; it’s not from the students,” Dude said. “I think a lot of people are unaware.”


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Comments

Ray Shapiro February 17, 2010 | 11:17 a.m.

("Post-DARE, who will provide substance abuse education?")
http://www.columbiamissourian.com/storie...

(Report Comment)
LEE TYREE February 17, 2010 | 1:10 p.m.
This comment has been removed.
Ray Shapiro February 17, 2010 | 1:57 p.m.

("LEE TYREE February 17, 2010 | 1:10 p.m.
Well i have been a avid smoker for 30 years and i tried the "legal" K2 last night and was not impressed. I think its a joke and would love to see and talk to anyone that said they were hospitalized. Waist of money! Guess thats why its legal and its not called dope.")
-Did it do anything to your coiffure?

(Report Comment)
Katy Bergen February 17, 2010 | 7:53 p.m.

As the writer of this article, I'd like to point out a paragraph in my story that needs clarifying.

K2 was not produced in a laboratory at Clemson University; the compounds JWH 018 and 073 were made at Clemson. They are combined with plant materials to use as the recreational drug/incense K2.

An e-mail sent by Professor Huffman yesterday said the following:

"I emphasize that this compound was not designed to be a super-THC. It is simply one of many compounds synthesized by my group and others for the purpose of investigating the relationship between chemical structure and biological activity. It should absolutely NOT be used as a recreational drug."

(Report Comment)
Ray Shapiro February 17, 2010 | 8:55 p.m.

("They are combined with plant materials to use as the recreational drug/incense K2.")

Is playing with recreational drugs the same as playing recreationally with fire?

(Report Comment)
Jason Red May 1, 2010 | 7:28 p.m.

Let me say this and please do not take this lightly. I smoke weed and have for many years! I drink. I like to use Mushrooms and Acid. I do not reccomend anyone try them. There are pros and cons to any of these things. This is not the time for me to go into that. Let me say out of all those "drugs" I have never had a bad trip. I smoked an off brand of K2 or synthetic weed.It was called spike gold. It was the single worst high I ever had. I took 3 or 4 hits and was high in about 2 min. At first the high was exactly like weed. Then about 10 min into it My heart beat started to get my attention. It started to beat harder and faster. I thought I was going to die or at the very least was having a heart attack. The pain was really bad but the fear of dying was worse. It lasted for a while. I would normally go to sleep if I drink too much or smoke too much. But this drug made me think I was never going to wake up so sleep was not an option. I almost called 911. It's been two days and I feel pretty good. This is just a warning. I am not trying to scare you.

(Report Comment)
Alex Vejar August 1, 2010 | 12:40 a.m.

I had a friend that was with me smoking K2 that experienced a really bizarre thing. There were about three of us that did it. But whatever happened to him was very similar to the effects marijuana can have on the brain. At first he put his hands over his face and then started climbing on the chair he was sitting in saying "I gotta get out of here." He walked around and he was hallucinating left and right and saying things that made no sense. He kept saying he was in a dream world and he literally thought he was going to die. He told us to tell his parents goodbye for him. This drug definitely has some very negative side effects and I believe it is very dangerous. These effects lasted about 2 hours before we just made him go to sleep. I believe it affects everyone differently but when it does affect someone, it can be dangerous.

(Report Comment)
Alexandria Francis August 14, 2010 | 7:35 p.m.

The same exact thing happened to me, Jason. My heart started beating out of control and I became white as a ghost. I thought I was dying or having a heart attack...or both. I've been smoking the real thing for quite some time now and have never once experienced such horrible side effects. I've dabbled and other drugs in the past, and none made me feel as close to death as K2. We should add this to the hundreds of other relevant reasons marijuana should be legalized. If marijuana was legal no one would have ever thought to try K2. Way to go, America. It's such a shame that our government is so ignorant.

(Report Comment)
tom kelly August 14, 2010 | 9:31 p.m.

Well, why would anyone want or need synthetic marijuana???

The legal one can kill you, and the illegal one calms you.
The legal one poisons you, and the other gets you prison.
Does any of this make sense?

Hey, I've found a way to make synthetic hops for my beer.
You don't get drunk. You just go crazy and crash into DWI checkpoints.

I think there's a market.

(Report Comment)
tavan eftekhar December 1, 2010 | 3:21 p.m.

I'd like to clarify.. Some people claim they smoked it and it did not do much.. I've used it, seen my friends use it, some people don't get much out of it the first time. It took me 4-5 times before I felt a normal high. After that I just did it because it was easier to get than marijuana. Eventually it had been a year and I realized I'd been using it almost daily. The past few times I used it I thought my teeth were going to fall out and my eyes felt like they were exploding. My throat was swollen and I was making much more mucus than usual. This stuff gets scary, it IS addictive (I felt the withdrawal like no other when I actually tried to stop, it is NOT like weed). Just because it takes hundreds of uses to become dangerous/addictive doesn't mean you should promote it or assume that it's safe. I'll never smoke it again now that I know. Once again... It took a year. Spread the word, get more studies done.

(Report Comment)
maria smith December 1, 2010 | 6:47 p.m.

i've been smoking k2 for about a month. the only reason i even care for it is because im a regular weed-smoker and my job drug tests randomly. it does give me an intense high and i feel wary every time i smoke it, but it beats the alternatives (getting fired, or staying sober.) it certainly wouldnt be my first choice, simply because of the intensity, but its what im stuck with.

yet another reason that weed should be legal.
this country needs a wakeup call.
nobody wants to quit smoking weed.
we'll just find alternatives if we must.

(Report Comment)
Parker Richard January 28, 2011 | 7:38 p.m.

Ive smoked synthetic Marijuana for about 7 months now on almost a daily basis. The reson for doing oso is because I have been forced to give up my use of Marijuana. I smoked Space for a while and literally never had a bad trip, always good. Recently I have smoked Kush (another brand) and have been pleased. I have noticed no serious difference between Marijuana and synthetic stuff but recommend real herb because in reality, Synthetic users have NO idea what we are doing to our bodies for the long run.

(Report Comment)
Roy Webb January 29, 2011 | 1:21 a.m.

I used to smoke Southern Spice on an almost daily basis starting August until mid-September of 2010. It was similar to marijuana of course, but there was a difference. I guess the best way I can describe its difference is: everything that you see, is all that exists, and there's nothing beyond your vision. You're literally in the moment and it's surroundings.It was fun of-course, but different.
Anyways I had my first and only bad trip on it during September 26 2010. I'll never forget it. I felt so unfamiliar and out of touch with everything. I was with my girlfriend who I love dearly, but during that bad trip I questioned who she was, her existence, and my own. Music sounded freakishly unfamiliar, and everything just felt weird. All that kept me sane was the though that "this is a drug effect, and it'll be over"
ANYWAYS....I stopped after that, threw the bag out of the window actually. November-ish I would slightly get the "bad trip" feeling randomly as I did every-day things. It got worse as time went on. I broke down in tears whilst driving one day because it just felt so wrong not to understand ANYTHING during a severe feeling of this "trip". I basically live with this feeling now, it isnt as severe, but it has its times where it'll just get scary,My heart will race from the anxiety and the thoughts of losing sanity during these intense sessions. I'm currently trying to fix and even find someone that can relate, whatever way I can. -being a struggling college and jobless student of the age of 19.
Some of my friends still do it, but of course they're too in the moment to listen and make proper decisions based on my bad experience.-But hopefully the reader/user will make better decisions.

(Report Comment)
Ryan Moore February 5, 2011 | 4:50 p.m.

Robb, i have had the same experience. I have been a daily user for a year now, starting when i went on probation. I just quit Sunday after having 3 prior trips, that sent shooting pains through heart and body trips. Even when i first started smoking i said, "it makes you see reality for what it is, and it almost made life seem depressing." When i smoked with friends everything was usually good. In the course of smoking, my head would start to hurt more throughout this year, i would gain tolerances to different synthetics, so then i would change what kind i smoked. In a way i feel like it turns you against yourself, but the anxiety only acts up when i am alone. As long as i am preoccupied i am alright. But since Sunday some days better then others but not the whole day. I am 19 as well from Troy, Michigan. It scares the F*** out of me because i don't know how long it lasts. Does it progressively get worse, or has it slowly been getting better? Hang in there bro, im on the same boat.

(Report Comment)
Paul Allaire February 5, 2011 | 7:50 p.m.

Really?
I tried it a few times with others who were smoking it instead of their usual. At it's onset it felt like weed, but typically it faded off almost as quickly as it came on. I found myself and others smoking it repeatedly where we might have smoked weed only once over the same bit of time. It generally left me feeling a bit dirty from the inside out - a feeling I attribute to a small temperature rise probably induced by a briefly elevated heartbeat. Marijuana with a similar initial punch generally leaves me quite high for a long time. So in that sense, it may be "more potent" than THC, but one is real and the other not. What would be more accurate is "negative side effects are more pronounced". Unfortunately, the undesirable side effects seem to be the entire experience. Some people call it a "businessman's high" because they can smoke it, feel a rush and then go back to work and be sober shortly.
I smoke to be high when I finish and in that sense it fails. I also find that weed is less expensive. If weed were all like the junk we are discussing I would not smoke weed.
For the comments... Are you real people? "Bad trips." Really? WHAT trip?
For the author and the cop...
"The laboratory, an arm of the Johnson County Sheriff's Department, ran an analysis on K2 in October 2009 ..."
"“They found K2 to contain lab-produced drugs that act on the same part of the brain as marijuana,” Morris said."

Really? A forensic evidence laboratory was able to identify how a drug worked? NOT LIKELY. The correct statement would have been "They found K2 to contain lab produced drugs of a type originally created to act on the same part ..." I could have endured that, but I get annoyed when someone says something in a way that would imply more than it really did and the reporter swallows it. Or maybe the writer abbreviated the reality. Either way, it is now harder to believe the following...
"Morris said there has been little scientific research exploring the toxicity of K2 in the United States, but hospitalization cases have ...
Scientific studies ... were done ... in 2008. It ... caused psychotic episodes that resulted in increased hospitalizations and accidents, Morris said."
I agree with the first part of the first sentence but find the last sentence problematic. The "psychotic episodes" resulted in increased hospitalizations and accidents over what??? Am I to believe that a research facility would allow subjects to get to the point where they were a risk to themselves or needed hospitalized? Or should I note that a "reporter" complied with the agenda of a smooth talker.

I have no wish to use that being discussed AND no reason to believe what I read. Unlike what I am read, my own negative statements are credible.

(Report Comment)
Paul Allaire February 5, 2011 | 8:08 p.m.

Here is the complete sentence. It is so poorly written that it has caused me to evaluate my own reading skills. At first I had a distinct impression that the studies were done in Germany. Now I understand it to mean that some mouthpiece of some local police organization said that "Scientific studies were done." Can anybody tell me where the "scientific studies" were done, if they were done?

"Scientific studies on K2 compounds were done using a drug called Spice that emerged in Germany in 2008. It was made up of plant materials and the same compounds as K2 and caused psychotic episodes that resulted in increased hospitalizations and accidents, Morris said."

Because I'm tending to believe this...

"Morris said there has been little scientific research exploring the toxicity of K2 in the United States..."

and

"“The noise is from the media; it’s not from the students,” Dude said." But WAIT!!! Didn't the media write this?

I'm with Dude.

http://upload.wikimedia.org/wikipedia/en...

(Report Comment)
Ryan Moore February 5, 2011 | 9:08 p.m.

I'm not going to go out of my way to explain, or sound professional. I'm real. Fly a plane to meet me. This is all stated about two substances. Jwh-018,73. Most all are banned in all states. Accessible only online. Most new spices are made in a laboratory or a so called chemist who is making and producing from home, selling to stores as vendors and making a f Load of profit. There are no tests being done in any way shape or form, but its legal, and it does the job. You don't feel it the first couple times because it takes time to bind to your receptors. These drugs are far different then real THC. The drugs can harm you, no lie. Why cant you find anything or tests done. banned and labeled as drug of concern in Europe. Europe doesn't ban anything.

(Report Comment)
Spencer Rogers February 20, 2011 | 8:44 p.m.

I've been an avid smoker of spice for maybe a year and a half I've had many differend brands and I know all about how it feels for your heard to freak out. I just give it some time try taking deep breaths and wait fr it to pass. Recently, since all the old good stuff has been illigalized in califorina I decited to try a new blend, something that was recently made with a new chemical that isn't banned the name was flame it came in a clear container like usual with a black cap. I packed a fair sized bowl and lit it up. Since it was something new I only smoked half. As soon as I got inside I knew something was definitely wrong my head hurt worse than it ever has before here it is 4 days later and I'm having terrible pressure in my head since. Last night I went to the emergency room. They took a cat scan and found no bleeding. I receved meds but no luck so far. After smoking for a year and a half I can honestly say I'm done. Yesterday morning I went outside and smashed my pipe and Threw away around 3 grams. I always thought this was perfectly ok to smoke but I'm afraid it's either permanent brain damage or an anurism I'll be going to a nuroligest come tomorrow since today's Sunday i wish this upon noone please don't take things too far like I did. Wish me luck...

(Report Comment)
Nena Troutt February 28, 2011 | 11:31 p.m.

ok so ive done every drug possible and not proud of it mind u but k2 is really not nothin it has a short high and its like pot, some of you people sound like youve done meth its stupid this k2 stuff itsnt even as harmful as crack herione and meth its like pot w a lil kick but doesnt last long. ive smoked weed for years then had a short time with acid then a long time w dope and the effects some people are sayin happens to u smokin k2 is rediculous u wanna really experience hallucinations and be periniod go do some real acid or dope u have no clue so dont compare it u have no idea wat a bad trip is ive seen a man set himself on fire from a bad trip of acid and a man die from bein so parniod off dope that he shot himself so u dont kno wat a bad trip is sorry. i smoke k2 all the time, several different brands and its just a short lil high. Nothin big at all the only problem is u dont know wat ur smokin but that comes w every drug now a days u never kno wat ur getting but people dont care if they did they wouldnt do it!!!

(Report Comment)
Adam Jones March 12, 2011 | 4:16 a.m.

This is a question for Roy Webb and Ryan Moore. What you described is how I feel after smoking 'cloud ten'. I thought I was smoking a tobacco since my friend bought it at a smoke shop and it caused my body to shut down. I then had a bad trip which caused me to have the worst feelings possible. The only way I can describe it is pure hell or what I my thought was hell. I forgot who I was and thought my life was a lie and that I never existed. After coming back to reality I started vomiting and finally went back to bed. When I awake I felt OK so I went home, when I got home I went on a walk to clear my head. During my walk I starting feeling strange almost like I was in a dream and this feeling was not going away. This scared the sh!t out of me so I rushed home and starting researching the drug after talking to my friend about it. I discovered what is was and how it was a chemical that has never been tested on humans. This made things worst for me so 'not knowing' so I went to bed thinking I was going to sleep it off. Within two hours of sleeping I awoke with a racing heart and sweating all over my body. I felt like someone was trying to kill me or something was trying to get me. I was unable to go back to bed and this went out for about a week. during this time I was so tired from not sleeping and I had intense headaches accompanied by pressure in my head. I also still felt like I was in a dream state and had severe anxiety/depression. I almost committed suicide because I could not handle it anymore. I was able to find the urge to kill myself and things slowly started to get better. I was able to sleep almost the whole night and the headaches were easing up. I still suffered from the anxiety and felt like I was in a dream like state. I finally went to the doctors and I was told to get some rest, eat fruits & vegs and exercise. I also was prescribed anti depressants which I told a couple times, but stopped because they made me feel off. It now has been almost 5 months since that night and though I do feel better I am not who I used to be. I find it difficult to focus and I get lightheaded and dizzy a lot of time. SCREW SYNTHETIC MARIJUANA!!! It caused me to go through months of hell. I hate also knowing that is was an accident that I smoked since I thought I was something else and that one mistake could cause so many problems. Back the original question I was wondering if you two found any relief and if so what did you do, thank you.

(Report Comment)
Dandi Steimel April 15, 2011 | 1:38 p.m.

My husband bought some called smiley from gas station. He said it was awful. But since then he's had to do a hair drug test for his job and it came back positive 4 the! He hasn't smoked pot in years! Has this happened to anyone else?

(Report Comment)
John Schultz April 15, 2011 | 2:11 p.m.

Maybe your husband should stick to beer until his employer lightens up?

(Report Comment)
Steve Spell II September 20, 2011 | 3:19 p.m.

Ah...Republicans attack United States Commerce UNLAWFULLY! Only the Federal Government can Consitutionally regulate interstate commerce. This is a crime being commited. More on this breaking synthetic marijuana scandal on my website at; www.demlegalscents.com
We need to round up all of these officials that are unduly burdening interstate commerce and LOCK EM UP! Period. This local seizure of United States Assets is a direct violation of the Anti Trust Laws; title 15 monopolizing trade a FELONY! Here is the full story; http://youtu.be/oDxKjfElK_g

(Report Comment)
Gerald Shelnutt September 20, 2011 | 4:10 p.m.

It's call dope cause that is who uses it.

(Report Comment)
Paul Allaire September 20, 2011 | 6:18 p.m.

It's call(ed) dope (be)cause that is who uses it.

(Report Comment)
Josie Jones September 21, 2011 | 3:55 p.m.

If it weren't for the prohibition of marijuana, folks would not buy k2 incense alternatives. Why would they? If people had legal access to the real deal they would not be hunting down k2 herb and the like. Just as the government has wasted endless resources chasing down marijuana, now they are going to do the same with this incense stuff. It is ridiculous and wasteful in more ways than one. How long have these products been banned, and there are still places advertising legal everywhere products like those found at http://www.buyk2.com .

(Report Comment)
Nikki Dawes November 21, 2011 | 1:05 p.m.

I would like everyone to know that this drug can effect everyone differently. I smoked with 5 people and none of them tripped out like I did. I took two hits, and almost immediately I started going crazy. This bad feeling came over me and I couldn't tell when my eyes were open or closed. I felt like everything was ugly, my friend kept saying "What's wrong, Nikki?" and I could tell I was freaking but I couldnt do anything to stop it. The peoples house i was at dipped as soon as I started tripping, and these boys kept telling her I just hit the smoke wrong. I was going crazy and crying and I felt like I had had premonition this was going to happen when I was a kid. It was like my own personal hell. I must've blacked out a bit, cause next thing i know I'm outside and I'm running. Everything in the world looks the same and forever, all my fingers look like thumbs and I'm just trying to get to something different. I have this thought: "I think you've gone crazy nikki." and imagine that replaying over and over in your head as you walk around trying to see details or something different. The worst part is it's like all the things your parents ever told you come true and all you can think or believe is that your gonna be a vegetable in a crazy people hospital. My "friends" have disappeared and I'm sure i've gone completely bonkers. I walk up to this lady and ask her to call 911 because I'm going crazy. My heartbeat was going 140. I'm not telling you not to use it, but what can happen on it is not worth taking the risk. I'm so grateful that I didn't stay crazy forever, and its not something I would recommend. Now listen, I had no idea I was smoking sythetic weed or that even such a thing existed until the boys told my friend. I've never blacked out in my life and I've never had a physcotic episode on regular weed.

(Report Comment)
israel moreno November 25, 2011 | 4:49 a.m.

Ive read most the comments in this forum and i feel a bit dummer as a result.

(Report Comment)
Mike Viktry December 9, 2011 | 5:02 a.m.

I've smoked synthetic marijuana 6 times. My first time was the only bad trip I had. My heart was beating very fast that I had to ditch my friend just to go wash my face and lay down on my bed. I ended up passing out. I was angry at the fact that I tripped out so bad from it, that I called up my friend to give it another try. I kept myself under control and enjoyed the high instead of freaking out. I'd prefer real marijuana more though. The high I get from smoking synthetics feels trashy but is very strong. The synthetic marijuana I smoked was called "White Rhino".

My other friend had the same experience as me, but felt light headed and slow afterwards.

(Report Comment)
Karen Dobner December 10, 2011 | 5:12 p.m.

My son, Max Dobner, went to the mall on June 14, 2011 and bought iAroma. He and his best friend discussed that it much be safer than marijuana because it was legal. They smoked it on the way home from the mall and she dropped him off. He looked fine at the time. 15 minutes later, he called his brother and said "I smoked that legal stuff. My heart is pounding and I'm having an anxiety attack." His brother told him to eat, take a shower and lay down. 20 to 25 minutes later, he left the house in a rush, leaving the doors wide open and the animals out, which was very uncharacteristic of him. He got into his car and drove at speeds reported by other drivers to be at speeds approaching 100 miles an hour. He drove into a house and died. Luckily, he didn't kill anyone else. Max was what a lot of people have characterized as the most perfect person they have ever met. He was an amazing human being. He had never been in trouble in his life. I can't tell you what his death has done to us. My friends and I have since founded the To the Maximus Foundation to educate and inform about the danger is synthetic marijuana. I get calls daily from people that have experienced what is commonly referred to as the "worst experience" of their lives. The stories I'm reading here are mild compared to some of the stories that are told to me. Deaths, heart attacks, what appears to be brain damage, suicides, ect. I hear horror stories all the time. People do the craziest things on these synthetic drugs. Everyone reacts differently to each of the research chemicals that are used. They call them research chemicals because they are for research only and have never been studied, or I should say we don't have the studies in yet. There are 500 (minimum) chemicals used that are currently being used to produce fake pot and the makers switch between chemicals and blends of chemicals, all the time. Every package has a random potency and every piece within the package has random potency. You never know when you are going to get a "hot spot", which means a very strongly sprayed, potent piece of whatever plant materiel that was used. Another words, every package is a mystery package; you don't know the chemical used or the potency. It's like playing RUSSIAN ROULETTE!!!!!!!

(Report Comment)

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