The Missouri baseball team lost 8-4 on Saturday at Oklahoma to fall to 3-8 in Big 12 Conference play and 18-16 overall.
Tigers starter Blake Holovach (5-2) suffered his second straight loss, giving up seven earned runs in 5 2/3 innings.
With the game tied at 4 with two outs in the bottom of the sixth, Holovach, a junior left-hander, gave up a two-run home run to the Sooners' Hunter Lockwood, and the Tigers sent in John Miles in relief after Holovach walked the next batter.
Miles had no better luck, giving up another two-run home run to the Sooners' Evan Mistich, before getting the third out on a strikeout.
Conner Mach led Missouri at the plate, going 2-for-4 with a run scored, while Eric Garcia went 1-for-4 with a pair of runs driven in.
Blake Brown extended hitting streak to 21 games, while Brannon Champagne reached base for the 26th consecutive game.
The Tigers and Sooners will play the final of the three-game series at 1 p.m. Sunday at L. Dale Mitchell Field in Norman.
Missouri lost the first game of the series in a game that featured a 3 hour, 39-minute rain delay after tornadoes were reported in the Norman area. The Tigers fell 6-5 after Missouri scored runs in the ninth and 10th innings to go ahead 5-4, then gave up a pair of two-out runs in the 10th.