Kansas got behind Oklahoma after an interception on the game's first play, and Nebraska had eight turnovers in a sloppy loss to Iowa State.
The Missouri defense also had some communication difficulties.
Texas quarterback Colt McCoy passed for three touchdowns in the first half against the Missouri defense, putting the game out of reach by halftime.
Injury forces Missouri football team to call on walk-on backup Jimmy Costello
Colt McCoy passed for three touchdowns in the Texas win over Missouri on Homecoming
Both players and fans arrived at the game with much anticipation. On Homecoming, former members of Marching Mizzou led pregame festivities. A Texas fan said seeing out-of-place Texas A&M clothing at a Texas game signals a Longhorn victory.
The Missouri Tigers lost to the Texas Longhorns 41-7 on Saturday at Memorial Stadium. Missouri quarterback Blaine Gabbert left the game after aggravating an injury and left the game. Backup Jimmy Costello entered the game and threw two interceptions.
For a school that claims to have invented homecoming, Missouri really botched this one. Here's 10 reasons why Texas was a bad choice for a homecoming guest.
When other Missouri football players were struggling to make their target times, Carl Gettis channeled his off-the-field outgoing side to motivate his teammates.
Missouri quarterback Blaine Gabbert sprained his right ankle Oct. 8 against Nebraska, but he said he feels healthy going into the team's game Saturday night against No. 3 Texas. Gabbert threw five interceptions in the last two games, which were both Tiger losses.
Missouri linebacker Sean Weatherspoon leads all Missouri athletes in Twitter followers, beating Missouri basketball player Kim English in a contest that started this August.
No. 3 Texas arrives in Columbia on Saturday with some of the most dangerous special teams in the country.
Texas quarterback Colt McCoy says he is past early season ailments that have frustrated him at times, despite leading the Longhorns to a 6-0 record.
In his weekly press conference, Missouri coach Gary Pinkel said that despite Blaine Gabbert's injury he still felt the sophomore quarterback was functional and gave his team the best chance to win.
Iowa State got its first conference win in two seasons with a comfortable win over Baylor. Texas Tech got its first road win with quarterback Steven Sheffield at quarterback, upsetting Nebraska in Lincoln.
Back-to-back losses always trigger an examination of problem areas. It was clear against Oklahoma State, though, that the Missouri running game showed considerable improvement in the first half.
With No. 3 Texas up next, the Missouri football team fell to 0-2 in Big 12 Conference play after a 33-17 loss Saturday at Oklahoma State.
Dez Bryant, Oklahoma State's star wide receiver, was unavailable Saturday night against Missouri following a suspension from the NCAA in early October. Some fans could be seen wearing T-shirts that read "FREE DEZ".
Rooting for Texas to beat the rival Sooners was a popular choice in Stillwater Saturday.
Liberty senior Marcus Lucas looks to his mother for guidance not only through life, but through his football career and college recruitment. While Missouri is high on Lucas' list, Tennessee, Stanford, and Oklahoma have also made offers.