After rain forced the Tigers to leave their series with the Aggies at a 1-1 tie last season, Missouri hopes to take the series to start SEC play this season.
The Tigers defeated Illinois State 11-10 and Radford 7-1 on Saturday in Kissimmee, Fla.
The Tigers beat Bradley 1-0 and Syracuse 9-7 in eight innings Friday to kick off the Citrus Classic in Kissimmee, Fla.
If they make the team, it would be Rhea Taylor's fourth appearance and Nicole Hudson's second on the national team.
The game will begin at 3 p.m. Saturday in the Devine Practice Facility.
Freshman Natalie Fleming followed in her sister's footsteps as a Missouri softball player from the small town of Silex, Mo. Her sister, Ashley, played Missouri softball from 2009 to 2012 and was the team's best hitter in 2011.
Three other SEC schools finished ahead of Missouri in the polls: No. 2 Tennessee, No. 5 Florida and No. 10 Alabama.
Missouri's Chelsea Thomas signed with the USSSA Florida Pride on Thursday after being selected as the squad’s 20th overall pick in the NPF draft on April 3.
The Missouri program's winningest pitcher at 111-31, Chelsea Thomas went 24-6 in 2013 with a 1.16 ERA, which ranks sixth in the nation.
The Missouri Athletic Department needs to finalize a location, seek board approval and work out the funding before it can move forward with plans for a new softball stadium.
Senior ace Chelsea Thomas allowed just two hits to Washington, but with a lack of Missouri offense, a Huskies home run ended up costing Missouri its season.
Defensive errors by Missouri and late rallies by Washington allowed the Huskies to win the first game of the series 2-1.
With a career ERA of 1.22 and the most strikeouts in Missouri softball history, Chelsea Thomas has led an illustrious college career, but her days as a Tiger are nearing an end.
The Tigers ended last season in the Super Regionals and missed the Women’s College World Series. Their coach hopes that doesn't happen again.
After being run-ruled in the first game Sunday, Missouri battled back to stave off elimination and advance to the next level of the NCAA Softball Tournament.
Winner moves on, loser goes home in deciding regional title game Sunday.
Missouri's Chelsea Thomas finished off Hofstra in the seventh. The Tigers escaped from a game where they were outhit eight to one, played badly at times and needed some luck to win.
Missouri's Chelsea Thomas and Hofstra’s Olivia Galati, who face each other Saturday in the NCAA Columbia Regional at University Field, have a combined 22 career no-hitters and eight perfect games.
With her teammates struggling at the plate, senior Nicole Hudson stepped up in Chelsea Thomas's absence to lead the Tigers past Stony Brook 3-0 in Friday's NCAA regional opener.
Doctors think Thomas is suffering from exertional compartment syndrome, a condition that causes her hand to go numb after arm muscle exertion.