Ervin Santana pitched eight strong innings, Alcides Escobar doubled home the go-ahead run and the Kansas City Royals rallied to beat the Minnesota Twins 3-1 on Monday in their home opener.
The Cardinals chased Cain (0-1) while scoring nine times in the fourth inning. The last two runs came home on Carlos Beltran's single off reliever Jose Mijares.
Billy Butler's fifth-inning homer, the first slam of his career and the first ever allowed by Philadelphia left-hander Cole Hamels, put Kansas City ahead 6-4.
Chris Porter scored the game's only goal in the St. Louis Blues' 1-0 win over the Detroit Red Wings. With the win, St. Louis moved into a tie with Minnesota for sixth place in the Western Conference.
Royals closer Greg Holland walked three in the ninth inning and gave up three runs in the Royals' 4-3 loss Saturday night.
Carlos Beltran hit a go-ahead single in the fifth inning to spur a Cardinals win over his former team.
Cliff Pennington's single in the 16th inning gave the Diamondbacks a 10-9 victory in a game that didn't end until early Thursday. At 5 hours and 32 minutes, it was the longest home game ever for in Diamondbacks.
Jeremie Guthrie struck out nine and gave up one run in six innings for the Royals, who picked up their first win of the season on Thursday, 3-1.
St. Louis' Adam Cracknell scored his first two goals of the season in the Blues' 4-3 win on the road.
Chicago White Sox start the season with two wins against the Royals - a team they struggled with last season
It's been tough slogging for a franchise that put up 109 points last year and was the No. 2 seed in the West but hasn't been able to duplicate a mix of shutdown goaltending.
The Arizona Diamondbacks used 15 hits to beat the St. Louis Cardinals 6-2 in their season opener Monday night in Phoenix.
Busch Stadium plans to host a game on May 23 between Manchester City and Chelsea.
Wainwright will be staying with the Cardinals for a while after agreeing Thursday to $97.5 million, five-year contract covering 2014-18.
The Cardinals on Tuesday announced they will let fans pick whether the team should stick with navy blue caps for road games, or go red. Red caps are worn at home.
Jaden Schwartz and Patrik Berglund both scored in the third period for St. Louis in a 3-2 loss Tuesday night at Vancouver.
Jake Allen made 29 saves on the night, leading the Blues to a 3-0 win.
Former Tiger Christine Flores signed with the WNBA's San Antonio Silver Stars Thursday.
Hours later, Cassel reached an agreement to join the Minnesota Vikings as the backup for Christian Ponder.
The Rams also remain in the hunt for free agent tackle Jake Long.