Shane Bieber pitched out of some early trouble before extending his strikeout record and César Hernández hit a two-run homer, sending the Cleveland Indians to a 3-2 win over the Chicago Cubs on Tuesday night at home.

Bieber (4-2) struck out eight and has now fanned at least that many in 20 consecutive starts, a major league mark he builds on every time out. The right-hander’s streak was in jeopardy, but he got Nick Martini for strikeout No. 8 in the seventh.

The reigning AL Cy Young Award winner wasn’t as sharp as usual and needed a career-high 121 pitches to go 6²/³ innings.

James Karinchak finished the seventh for Bieber and worked the eighth. Emmanuel Clase gave up two singles in the ninth, but got Matt Duffy to bounce into a game-ending double play for his seventh save.

Hernández homered in the fifth off Adbert Alzolay (1-3), who matched Bieber for six innings.

José Ramírez added a solo homer for the up-and-down Indians, who have been no-hit twice but won seven of eight.

Blue Jays 5, Braves 3: Vladimir Guerrero homered and drove in three runs and the Toronto Blue Jays took advantage of Atlanta’s indecisive fielding in the eighth inning on the road, rallying past the Braves.

Guerrero had three hits, including a tying single in a three-run eighth.

Ronald Acuña Jr. hit his major league-leading 11th homer for Atlanta. Marcell Ozuna also connected.

The teams opened the three-game interleague series less than two weeks after the Blue Jays swept three games from the Braves in Dunedin, Florida.

Robbie Ray set a season high with 10 strikeouts while giving up three runs on five hits, including two homers, in six innings.

Pirates 7, Reds 2: Troy Stokes Jr. drove in runs with each of his first two major league hits, JT Brubaker pitched six strong innings and the Pittsburgh Pirates finally beat the Cincinnati Reds, in a home night game.

Two days after making his debut, Stokes hit an RBI single in the fourth inning. The right fielder also doubled in a run in the eighth.

Brubaker (3-2) allowed one run on five hits to win for the first time in four starts. He had four strikeouts and one walk.

The Pirates had lost eight straight games to the Reds, including all four this season by a combined score of 44-9. Pittsburgh has won three of its past 12 overall.

NL batting leader Jesse Winker homered and doubled twice for Cincinnati to raise his average to .374.

Athletics 3, Red Sox 2: Chris Bassitt struck out a season-high 10 over seven effective innings and the Oakland Athletics beat the Boston Red Sox at Fenway Park in a matchup of American League division leaders.

Matt Chapman and Elvis Andrus hit RBI singles for the A’s in the seventh inning as Oakland broke a 1-all tie with two runs. Matt Olson also had an RBI single for the A’s, who opened six-game road trip with a victory.

Yusmeiro Petit pitched a scoreless eighth and Jake Diekman got his fourth save despite walking two batters in the ninth.

Rafael Devers homered for Boston, which has lost two straight since winning four in a row.

Bassitt (3-2), whose previous high for the season was nine strikeouts on April 29 at Tampa Bay, allowed just three hits and two runs. He hurt himself in the first with a pair of wild pitches that helped Boston take a 1-0 lead. But he settled down nicely after J.D. Martinez’s sacrifice fly, retiring 14 straight batters before Michael Chavis singled with one out in the sixth.

Red Sox starter Nathan Eovaldi lasted six innings, holding Oakland to one run on two hits and two walks. He struck out four before Darwinzon Hernandez took over in the seventh. After Olson drew a leadoff walk, Jed Lowrie and Chapman followed with back-to-back singles as Oakland took its first lead.

Mets 3, Orioles 2: Patrick Mazeika got his second walk-off RBI in four career games with a fielder’s choice grounder in the ninth inning Monday at home, helping the banged-up New York Mets rally to beat the Baltimore Orioles for their sixth straight win.

Baltimore led 2-1 entering the ninth after John Means out-dueled Marcus Stroman in his first start since throwing a no-hitter last week.

Means had five days of rest after no-hitting Seattle last week, when he threw a career-high 113 pitches in what was also his first complete game. He got a lighter workload Tuesday, throwing just 74 pitches over six innings with six hits allowed and three strikeouts.

Orioles manager Brandon Hyde said he wanted to limit the 28-year-old, a strategy made easier when Means’ spot in the order came up with the bases loaded and one out against Stroman in the seventh.

Stroman was charged with one run in 6⅓ innings, lowering his ERA to 2.01. He allowed four hits and two walks while striking out five, cruising into the seventh before loading the bases on two hits and an intentional walk.

Yankees 3, Rays 2: Jordan Montgomery pitched six strong innings, Aaron Judge and Gary Sánchez homered, and the New York Yankees beat the Tampa Bay Rays in St. Petersburg, Florida.

About two hours before the start, it was announced that Yankees third base coach Phil Nevin is away from the team after a positive COVID-19 test.

The Yankees beat Tampa Bay for just the second time in seven games this season. The AL champion Rays had won 18 of the last 23 meetings, including a five-game victory in last year’s Division Series.

New York slugger Luke Voit went 0 for 3 in his first game this season. The major league home run leader last year with 22, he was reinstated from the 10-day injured list after having knee surgery on March 29.

Voit was hit by a pitch around the right wrist in the fourth inning and had a flyout to the right-field wall in the seventh.

Montgomery (2-1) gave up one run, two hits, walked one and tied a career high with nine strikeouts. After Jonathan Loaisiga worked two innings, Aroldis Chapman got three outs to get his eighth save and complete a three-hitter.

Chapman had an eventful ninth, including a visit by a trainer. Austin Meadows reached on shortstop Gleyber Torres’ error, but Sánchez later threw out the Rays DH attempting to advance to second. The lefty also walked one and struck out one.

Judge started in right field after being rested Sunday and hit a first-pitch, first-inning solo homer off Luis Patiño (1-1). Judge, who entered with two hits in his previous 24 at-bats, has been dealing with what manager Aaron Boone is calling “lower leg stuff.”

Sánchez made it 3-1 with his shot in the seventh off Josh Fleming. It was his second homer in three games after a career-high tying 18-game homerless streak.

Mike Zunino connected on a 472-foot solo drive in the third for the Rays. It was the fourth longest homer in MLB this season, behind Yermin Mercedes (485 feet), Ronald Acuña Jr. (481 feet) and Marcell Ozuna (479 feet).

Patiño allowed two runs and three hits in four innings.

Astros 5, Angels 1: Shohei Ohtani struck out 10 in an impressive duel with Lance McCullers Jr., and the Houston Astros broke loose at home against the Angels’ bullpen to beat Los Angeles.

Ohtani allowed one run and four hits with one walk in seven innings, solving his control troubles in his longest start of the season. The two-way star then moved to play right field, and Yuli Gurriel homered during Houston’s four-run eighth.

Ohtani batted second and went 1 for 4, striking out twice.

McCullers (3-1) yielded three hits, including a homer by Taylor Ward, while tying a season high with nine strikeouts in going eight innings, his longest start this season. He walked two.

Angels reliever Aaron Slegers (2-1) walked Martín Maldonado to begin the eighth and Aledmys Díaz singled with one out. Alex Claudio took over and was greeted with an RBI single by Michael Brantley that put Houston on top 2-1.

Gurriel homered with two outs.

Ohtani’s appearance in right field marked the second time in his MLB career that he’s played a position other than pitcher. He played left field for an inning in his last trip to Houston this season.

It was the third time this season that he’s hit on the same day he’s pitched, making him the first player in MLB history to do so in three games where a designated hitter was available, passing Ken Brett, who did it twice in 1976 for the White Sox.

Ohtani had allowed just two singles when Tucker opened Houston’s fifth with his solo shot to the seats in left field to put the Astros up 1-0.

McCullers had given up only one hit and retired 11 in a row when Ohtani singled to start the seventh. Mike Trout walked after that, but Jared Walsh grounded into a double play before Justin Upton grounded out to end the threat.

There was one out in the eighth when Ward homered to the third row of the seats in right field to tie it at 1-all.

Giants 4, Rangers 2: Logan Webb tied a career high with 10 strikeouts in six innings and the San Francisco Giants beat Texas at home, keeping the Rangers winless in interleague play this season.

Swept in the two-game series, Texas dropped to 0-5 against NL opponents this year. The Rangers have lost a team-record nine straight interleague games overall — their next try to end the drought will be June 1 at Colorado.

Mike Yastrzemski and Brandon Belt drove in runs for San Francisco, which began the day tied with St. Louis for the best record in the National League.

David Dahl launched his third home run of the season for Texas.

Webb (2-3) allowed two runs and three hits to earn his first win in his last three starts. Jake McGee pitched a perfect ninth inning for his 10th save.

Jordan Lyles (1-3) gave up two runs in five innings, striking out six. He has lost three straight decisions since he won his first start of the season on April 4.

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